Bisintercalator-containing dinuclear iron(III) complex: An efficient artificial nuclease.

نویسندگان

  • Xiaoqiang Chen
  • Jiangli Fan
  • Xiaojun Peng
  • Jingyun Wang
  • Shiguo Sun
  • Rong Zhang
  • Tong Wu
  • Fei Zhang
  • Jianfeng Liu
  • Fen Wang
  • Saijian Ma
چکیده

Two acridine groups were successfully introduced into di-iron(III) complex. DNA cleavage experiments indicated that complex conjugating bisacridine groups can enhance 300-fold for the cleavage efficiency compared with complex lacking of acridine conjugation. Further ligation assay of DNA segments provided the evidence for hydrolytic mechanism of DNA cleavage.

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عنوان ژورنال:
  • Bioorganic & medicinal chemistry letters

دوره 19 15  شماره 

صفحات  -

تاریخ انتشار 2009