Bisintercalator-containing dinuclear iron(III) complex: An efficient artificial nuclease.
نویسندگان
چکیده
Two acridine groups were successfully introduced into di-iron(III) complex. DNA cleavage experiments indicated that complex conjugating bisacridine groups can enhance 300-fold for the cleavage efficiency compared with complex lacking of acridine conjugation. Further ligation assay of DNA segments provided the evidence for hydrolytic mechanism of DNA cleavage.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 19 15 شماره
صفحات -
تاریخ انتشار 2009